Self-association of Cholesterol in Aqueous Solution

NMR investigation of self-association of vanillin in aqueous solution

Interactions of cholesterol with cyclodextrins in aqueous solution.

The interaction of cholesterol with several cyclodextrins (CDs) was investigated in water using solubility method. It was found that heptakis (2,6-di-O-methyl)-beta-CD (DOM-beta-CD) forms two types of soluble complex, with molar ratios of 1 : 1 and 1 : 2 (cholesterol : DOM-beta-CD), and neither a soluble nor insoluble complex is formed between cholesterol and alpha-CD, beta-CD, and gamma-CD, al...

Thermodynamics and kinetics of amphotericin B self-association in aqueous solution characterized in molecular detail

Amphotericin B (AmB) is a potent but toxic drug commonly used to treat systemic mycoses. Its efficiency as a therapeutic agent depends on its ability to discriminate between mammalian and fungal cell membranes. The association of AmB monomers in an aqueous environment plays an important role in drug selectivity, as oligomers formed prior to membrane insertion - presumably dimers - are believed ...

Self-Association of Cholesterol in Carbon Tetrachloride

Analysis of infrared hydroxyl multimer absorbances of dilute solutions of cholesterol in car bon tetrachloride as a function of the monomer absorbance strongly favours the interpretation of the association of this alcohol with a monomer-dimer-tetramer model up to a molar fraction of 0.012. This model also explains very well the concentration dependence of the apparent dipole moment. Equilibrium...

Self-association of organic solutes in solution: a NEXAFS study of aqueous imidazole.

N K-edge near-edge X-ray absorption fine-structure (NEXAFS) spectra of imidazole in concentrated aqueous solutions have been acquired. The NEXAFS spectra of the solution species differ significantly from those of imidazole monomers in the gas phase and in the solid state of imidazole, demonstrating the strong sensitivity of NEXAFS to the local chemical and structural environment. In a concentra...